Influenza A virus infection induces liver injury in mice.
Identifieur interne : 000B19 ( Main/Exploration ); précédent : 000B18; suivant : 000B20Influenza A virus infection induces liver injury in mice.
Auteurs : Shouping Zhang [République populaire de Chine] ; Bin Hu [République populaire de Chine] ; Jingfei Xu [République populaire de Chine] ; Qiuxuan Ren [République populaire de Chine] ; Lirong Wang [République populaire de Chine] ; Sanhu Wang [République populaire de Chine]Source :
- Microbial pathogenesis [ 1096-1208 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Charge virale, Femelle, Foie (anatomopathologie), Foie (traumatismes), Foie (virologie), Grippe humaine (), Grippe humaine (virologie), Humains, Hépatite (anatomopathologie), Hépatite (étiologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (virologie), Modèles animaux de maladie humaine, Réplication virale, Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Sous-type H7N2 du virus de la grippe A, Transaminases (sang), Virus de la grippe A (pathogénicité).
- MESH :
- anatomopathologie : Foie, Hépatite.
- pathogénicité : Virus de la grippe A.
- sang : Transaminases.
- traumatismes : Foie.
- virologie : Foie, Grippe humaine, Infections à Orthomyxoviridae.
- étiologie : Hépatite.
- Animaux, Charge virale, Femelle, Grippe humaine, Humains, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Réplication virale, Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Sous-type H7N2 du virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Female, Hepatitis (etiology), Hepatitis (pathology), Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype, Influenza A Virus, H7N2 Subtype, Influenza A virus (pathogenicity), Influenza, Human (complications), Influenza, Human (virology), Liver (injuries), Liver (pathology), Liver (virology), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (complications), Orthomyxoviridae Infections (virology), Transaminases (blood), Viral Load, Virus Replication.
- MESH :
- chemical , blood : Transaminases.
- complications : Influenza, Human, Orthomyxoviridae Infections.
- etiology : Hepatitis.
- injuries : Liver.
- pathogenicity : Influenza A virus.
- pathology : Hepatitis, Liver.
- virology : Influenza, Human, Liver, Orthomyxoviridae Infections.
- Animals, Disease Models, Animal, Female, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype, Influenza A Virus, H7N2 Subtype, Mice, Mice, Inbred BALB C, Viral Load, Virus Replication.
Abstract
Respiratory infections such as SARS-CoV in humans are often accompanied by mild and self-limiting hepatitis. As a respiratory disease, influenza A virus (IAV) infection can lead to hepatitis, but the mechanism remains unclear. This study aimed to investigate the occurrence of hepatitis by establishing a model for infected mice for three different subtypes of respiratory IAVs (H1N1, H5N1, and H7N2). Histological analysis was performed, and results showed increase serum aminotransferase (ALT and AST) levels and evident liver injury on days 3 and 7, especially on day 5 post infection. Immunohistochemistry (IHC) results indicated a wide distribution of IAV's positive signals in the liver of infected mice. Real-time PCR results further revealed a similar viral titer to IHC that presented a remarkedly positive correlation with histology injury. All these data showed that the mouse model suitably contributed valuable information about the mechanism underlying the occurrence of hepatitis induced by respiratory influenza virus.
DOI: 10.1016/j.micpath.2019.103736
PubMed: 31505263
Affiliations:
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Electronic address: vet_sanhu@sina.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003</wicri:regionArea><wicri:noRegion>453003</wicri:noRegion></affiliation></author></analytic><series><title level="j">Microbial pathogenesis</title><idno type="eISSN">1096-1208</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Hepatitis (etiology)</term><term>Hepatitis (pathology)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza A Virus, H7N2 Subtype</term><term>Influenza A virus (pathogenicity)</term><term>Influenza, Human (complications)</term><term>Influenza, Human (virology)</term><term>Liver (injuries)</term><term>Liver (pathology)</term><term>Liver (virology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (complications)</term><term>Orthomyxoviridae Infections (virology)</term><term>Transaminases (blood)</term><term>Viral Load</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Charge virale</term><term>Femelle</term><term>Foie (anatomopathologie)</term><term>Foie (traumatismes)</term><term>Foie (virologie)</term><term>Grippe humaine ()</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Hépatite (anatomopathologie)</term><term>Hépatite (étiologie)</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Modèles animaux de maladie humaine</term><term>Réplication virale</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Sous-type H7N2 du virus de la grippe A</term><term>Transaminases (sang)</term><term>Virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Transaminases</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Foie</term><term>Hépatite</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hepatitis</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hepatitis</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Transaminases</term></keywords><keywords scheme="MESH" qualifier="traumatismes" xml:lang="fr"><term>Foie</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Foie</term><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term><term>Liver</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hépatite</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza A Virus, H7N2 Subtype</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Viral Load</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Charge virale</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Infections à Orthomyxoviridae</term><term>Modèles animaux de maladie humaine</term><term>Réplication virale</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Sous-type H7N2 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Respiratory infections such as SARS-CoV in humans are often accompanied by mild and self-limiting hepatitis. As a respiratory disease, influenza A virus (IAV) infection can lead to hepatitis, but the mechanism remains unclear. This study aimed to investigate the occurrence of hepatitis by establishing a model for infected mice for three different subtypes of respiratory IAVs (H1N1, H5N1, and H7N2). Histological analysis was performed, and results showed increase serum aminotransferase (ALT and AST) levels and evident liver injury on days 3 and 7, especially on day 5 post infection. Immunohistochemistry (IHC) results indicated a wide distribution of IAV's positive signals in the liver of infected mice. Real-time PCR results further revealed a similar viral titer to IHC that presented a remarkedly positive correlation with histology injury. All these data showed that the mouse model suitably contributed valuable information about the mechanism underlying the occurrence of hepatitis induced by respiratory influenza virus.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Shouping" sort="Zhang, Shouping" uniqKey="Zhang S" first="Shouping" last="Zhang">Shouping Zhang</name></noRegion><name sortKey="Hu, Bin" sort="Hu, Bin" uniqKey="Hu B" first="Bin" last="Hu">Bin Hu</name><name sortKey="Ren, Qiuxuan" sort="Ren, Qiuxuan" uniqKey="Ren Q" first="Qiuxuan" last="Ren">Qiuxuan Ren</name><name sortKey="Wang, Lirong" sort="Wang, Lirong" uniqKey="Wang L" first="Lirong" last="Wang">Lirong Wang</name><name sortKey="Wang, Sanhu" sort="Wang, Sanhu" uniqKey="Wang S" first="Sanhu" last="Wang">Sanhu Wang</name><name sortKey="Xu, Jingfei" sort="Xu, Jingfei" uniqKey="Xu J" first="Jingfei" last="Xu">Jingfei Xu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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